2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130825
    Bis-PEG13-NHS ester 2221949-00-2 98.0%
    Bis-PEG13-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG13-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG13-NHS ester
  • HY-W034597
    20-(tert-Butoxy)-20-oxoicosanoic acid 683239-16-9 99.9%
    20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
    20-(tert-Butoxy)-20-oxoicosanoic acid
  • HY-W019798
    NH2-PEG8-acid 756526-04-2 ≥98.0%
    NH2-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG8-acid also is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG8-acid
  • HY-140762
    Azido-PEG24-NHS ester 2375600-46-5
    Azido-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG24-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG24-NHS ester
  • HY-42427
    NH2-PEG2-CH2-Boc 1948273-09-3
    NH2-PEG2-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG2-CH2-Boc
  • HY-140691
    mPEG-Mal (MW 10000) 99.89%
    m-PEG-mal (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    mPEG-Mal (MW 10000)
  • HY-140614
    DNP-PEG4-NHS ester 858126-78-0
    DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DNP-PEG4-NHS ester
  • HY-W040231
    Fmoc-NH-PEG3-CH2CH2COOH 867062-95-1 99.79%
    Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG3-CH2CH2COOH
  • HY-W040244
    Boc-NH-PEG6-CH2CH2COOH 882847-13-4
    Boc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG6-CH2CH2COOH
  • HY-133392
    Azido-PEG5-azide 356046-26-9 99.98%
    Azido-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-azide
  • HY-140988
    Mal-NH2 TFA 146474-00-2 99.32%
    Mal-NH2 (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-NH2 TFA
  • HY-130410
    Bis-PEG6-NHS ester 1526718-98-8 ≥98.0%
    Bis-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG6-NHS ester
  • HY-W101722
    tert-Butyl (9-aminononyl)carbamate 510754-90-2 98.0%
    tert-Butyl (9-aminononyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    tert-Butyl (9-aminononyl)carbamate
  • HY-W012001
    N-Boc-7-aminoheptanoic acid 60142-89-4 98.0%
    Boc-7-Aminoheptanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-7-Aminoheptanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    N-Boc-7-aminoheptanoic acid
  • HY-130898
    BM-PEG3 86099-06-1 98.0%
    BM-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    BM-PEG3
  • HY-W007700
    8-Bromooctanoic acid 17696-11-6 99.89%
    8-Bromooctanoic acid is a PROTAC linker, and can be used for synthesis of PROTAC CYP1B1 degrader-2 (HY-158429).
    8-Bromooctanoic acid
  • HY-140756
    Azido-PEG1-NHS ester 1807530-06-8 99.78%
    Azido-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-NHS ester
  • HY-W044155
    Azido-PEG2-azide 59559-06-7 98.11%
    Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-azide
  • HY-W007341
    Pentaethylene glycol 4792-15-8 99.58%
    Pentaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Pentaethylene glycol
  • HY-43721
    N-Boc-4-pentyne-1-amine 151978-50-6 98.25%
    N-Boc-4-pentyne-1-amine is a PROTAC linker, which refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine can be used in the synthesis of the PROTAC MG-277 (HY-130122). N-Boc-4-pentyne-1-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-Boc-4-pentyne-1-amine
PROTAC Linkers Isoform Comparison

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